Protective Effect of Annona muricata Linn Fruit Pulp Lyophilized Powder against Paracetamol-Induced Redox Imbalance and Hepatotoxicity in Rats

In the current investigation, Annona muricata Linn. lyophilized fruit pulp powder was evaluated for its hepatoprotective activity induced by paracetamol or acetaminophen (APAP). Male Sprague Dawley rats were orally pre-treated 15 days with A. at low (1 g/kg b.wt) and high doses (2 b.wt). Silymarin (100 mg/kg) administered as standard drug. Hepatotoxicity using APAP, in a single oral administration of 2.5 body weight dosage on 15th day. Aspartate transaminase (AST), alanine (ALT), alkaline phosphatase (ALP) elevated APAP group but found to be significantly reduced groups dose-dependent manner. brought down serum total protein albumin levels significantly. The activities superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase administration; further, pool tissue also diminished However, powder, level antioxidant parameters near normal. A significant increase lipid peroxidation observed group, while silymarin, AML, AMH exhibited resistance (LPO), evident from lower LPO generated. Histopathological examination revealed considerable damage alone treatment which not devastating groups. Altogether, study concludes that is protective against APAP-induced liver injury modulating hepatic redox systems.